The COVID-19 public health crisis is placing tremendous stress on Canadians and our healthcare system. As COVID-19 knowledge is quickly evolving, current real-time data is often fragmented, incomplete, or focused on efforts to minimize mortality. Little is known about the day-to-day experience of Canadians who are self-isolating with possible, probable or confirmed COVID-19. While no patient-reported measures are “fit for purpose”, several may be useful. Optimizing patient-centred outcomes measurement will ensure COVID-19 research is comparable and meaningful to patients and families across studies and settings. Our goal is to collectively identify a core set of PRO domains, potential measures, and processes for COVID-19 PRO outcomes.